The use of mushroom-forming fungi for the production of N-glycosylated therapeutic proteins

E. Berends, K. Scholtmeijer, H. Wösten, D. Bosch and L. Lugones

Trends Microbiol 2009;17(10):439-43.

DOI PMID Cited by ~16

The market for N-glycosylated therapeutic proteins represents multi-billion dollars in sales and is growing more than 10% each year. This requires cost-effective production platforms that display correct and homogeneous N-glycosylation. Based on recent results, we propose to use mushroom-forming basidiomycetes for the production of N-glycosylated therapeutic proteins.