Severe traumatic brain injury is a leading cause of mortality and morbidity, and these patients are frequently intubated in the prehospital setting. Cerebral perfusion and intracranial pressure are influenced by the arterial partial pressure of CO The BRAIN-PROTECT study is an observational multicenter study. Patients with severe traumatic brain injury, treated by Dutch Helicopter Emergency Medical Services between February 2012 and December 2017, were included. Follow-up continued for 1 year after inclusion. End-tidal CO A total of 1776 patients were eligible for analysis. An L-shaped association between end-tidal CO A safe zone of 35-45 mmHg for end-tidal CO
Association between prehospital end-tidal carbon dioxide levels and mortality in patients with suspected severe traumatic brain injury
S. Bossers, F. Mansvelder, S. Loer, C. Boer, F. Bloemers, E. Lieshout, D. Hartog, N. Hoogerwerf, J. van der Naalt, A. Absalom, L. Schwarte, J. Twisk and P. Schober
Intensive Care Med 2023;49(5):491-504.