Effect of a Laparoscopic Donor Nephrectomy in Healthy Living Kidney Donors on the Acute Phase Response Using Either Propofol or Sevoflurane Anesthesia

B. Brattinga, H. Huang, S. Maslau, A. Thorne, J. Hunter, S. Knight, M. Struys, H. Leuvenink, G. de Bock, R. Ploeg, B. Kessler and G. Nieuwenhuijs-Moeke

Int J Mol Sci 2025;26(11).

DOI PMID

Surgical trauma elicits a complex inflammatory stress response, contributing to postoperative morbidity and recovery variability. This response is influenced by patient-specific factors and surgical and anesthetic techniques. To isolate the impact of anesthesia on the acute phase response, we investigated plasma proteomic changes in a uniquely homogeneous cohort of healthy, living kidney donors (