Population Pharmacodynamic Modeling Using the Sigmoid E

J. Proost, D. Eleveld and M. Struys

AAPS J 2020;23(1):10.

DOI PMID Cited by ~7

The relationship between the concentration of a drug and its pharmacological effect is often described by empirical mathematical models. We investigated the relationship between the steepness of the concentration-effect relationship and inter-individual variability (IIV) of the parameters of the sigmoid E