Publications of Michel Struys

2025

Papers in international journals

1. TabernéeHeijtmeijer ESE, Vos JJ, Freeman LM, Burger RJ, Terpstra-Prinsen EBF, Struys MMRF, et al. [Pain relief during childbirth: epidural analgesia, remifentanil or nitrous oxide?]. Ned Tijdschr Geneeskd. 2025;169.
   Abstract PMID
2. Gentile A, Introna M, Struys MMRF, van den Berg JP. Rapid sequence induction with target-controlled infusions: a technical simulation study. Anaesthesia. 2025.
   DOI PMID
3. Lapage K, Hoogma DF, Struys MMRF, Rex S. Impact of superficial and deep parasternal blocks on recovery after cardiac surgery with sternotomy. Comment on Br J Anaesth 2025; 135: 764-71. Br J Anaesth. 2025.
   DOI PMID
4. Veenker CGH, Redzhebov BB, Hoeks SE, van Eijk LT, Struys MMRF, de Hon O, et al. Effects of growth hormone and anabolic steroids, in critically ill patients admitted to the intensive care unit: a systematic review and meta-analysis. Sci Rep. 2025;15(1):36856.
   Abstract DOI PMID
5. Günkel PN, Yang S, Tuinhout RS, Luttik SJ, Hoffmann RF, Ottens PJ, et al. Optimizing Donor Kidneys During Normothermic Machine Perfusion With Sevoflurane: Design of a Research Model. Artif Organs. 2025.
   Abstract DOI PMID
6. Introna M, Carozzi C, Gentile A, Girasole R, Gemma M, Koomen JV, et al. Target controlled infusion in the intensive care unit: a scoping review. J Clin Monit Comput. 2025.
   Abstract DOI PMID
7. Massari D, Modestini M, Niezen CK, Yeh L, Zoutman AC, Scheeren TWL, et al. Intraoperative renal and cerebral tissue oxygen saturation measurements to predict postoperative acute kidney injury in pediatric cardiac surgery: a prospective observational study. J Clin Monit Comput. 2025.
   Abstract DOI PMID
8. Huisman GJJ, Berger SP, Thyrrestrup PS, Hausken J, Veelo DP, Guirado L, et al. Propofol-based versus sevoflurane-based anaesthesia for deceased donor kidney transplantation: the VAPOR-2 study protocol for an international multicentre randomised controlled trial. BMJ Open. 2025;15(9):e098965.
   Abstract DOI PMID
9. Tuinhout RS, Jongman RM, Nieuwenhuijs-Moeke GJ, Abdulahad WH, Struys MMRF, van Meurs M, et al. Effects of sevoflurane, propofol, remifentanil, and fentanyl on the endothelial proinflammatory response: an in vitro exploratory study. Can J Anaesth. 2025;72(8):1291-1304.
   Abstract DOI PMID
10. de Jong BT, Eleveld DJ, Mason KP, Struys MMRF. Clinical Pharmacokinetics and Pharmacodynamics of Remimazolam. Clin Pharmacokinet. 2025;64(9):1263-1282.
    Abstract DOI PMID Cited by ~2
11. Brattinga B, Huang H, Maslau S, Thorne AM, Hunter J, Knight S, et al. Effect of a Laparoscopic Donor Nephrectomy in Healthy Living Kidney Donors on the Acute Phase Response Using Either Propofol or Sevoflurane Anesthesia. Int J Mol Sci. 2025;26(11).
    Abstract DOI PMID
12. Colin PJ, Bichajian LH, Curt VR, Koomen JV, Stöhr T, Struys MMRF, et al. Pharmacokinetics and Pharmacodynamics of Remimazolam for Procedural Sedation in Children and Adolescents. Anesthesiology. 2025;143(2):368-382.
    Abstract DOI PMID Cited by ~1
13. Eleveld DJ, Colin PJ, den Berg JPV, Koomen JV, Stoehr T, Struys MMRF. Development and analysis of a remimazolam pharmacokinetics and pharmacodynamics model with proposed dosing and concentrations for anaesthesia and sedation. Br J Anaesth. 2025;135(1):206-217.
    Abstract DOI PMID Cited by ~5
14. Vellinga R, Koomen JV, Eleveld DJ, Stöhr T, Pesic M, Struys MMRF, et al. Influence of Remifentanil on the Pharmacokinetics and Pharmacodynamics of Remimazolam in Healthy Volunteers. Anesthesiology. 2025;142(4):666-679.
    Abstract DOI PMID Cited by ~4
15. Niezen CK, Modestini M, Massari D, Bos AF, Scheeren TWL, Struys MMRF, et al. Prognostic Value of Perioperative Near-Infrared Spectroscopy Monitoring for Postoperative Acute Kidney Injury in Pediatric Cardiac Surgery: A Systematic Review. Semin Cardiothorac Vasc Anesth. 2025;29(3):209-218.
    Abstract DOI PMID Cited by ~1
16. Kong D, Roberts JA, Lipman J, Taccone FS, Cohen-Wolkowiez M, Sime FB, et al. A Pooled Pharmacokinetic Analysis for Piperacillin/Tazobactam Across Different Patient Populations: From Premature Infants to the Elderly. Clin Pharmacokinet. 2025;64(1):107-126.
    Abstract DOI PMID Cited by ~3
17. Kalmar AF, Rex S, Vereecke H, Teunkens A, Dewinter G, Struys MMRF. Environmental Effects of Propofol Versus Sevoflurane for Maintenance Anesthesia. Anesth Analg. 2025;140(3):740-742.
    DOI PMID Cited by ~4

2024

Papers in international journals

1. Dercksen B, Struys MMRF, Paans W, Cnossen F. The nature, sequence and duration of professional activities of Emergency Medical Service providers: An observational study to evaluate quality of care using the steps in the EMS care process as described by the SPART model. PLoS One. 2024;19(12):e0311946.
   Abstract DOI PMID
2. Li Y, Koomen JV, Eleveld DJ, van den Berg JP, Vos JJ, de Keijzer IN, et al. Population Pharmacokinetic Modelling of Norepinephrine in Healthy Volunteers Prior to and During General Anesthesia. Clin Pharmacokinet. 2024;63(11):1597-1608.
   Abstract DOI PMID Cited by ~2
3. Vulcano TJ, Abdulahad WH, van Meurs M, Jongman RM, Struys MMRF, Bosch DJ. The Impact of Different Anesthetics on the Distribution and Cytotoxic Function of NK Cell Subpopulations: An In Vitro Study. Int J Mol Sci. 2024;25(20).
   Abstract DOI PMID Cited by ~4
4. Modestini M, Massari D, Huisman S, Struys MMRF, Roofthooft MTR, Vos JJ. Impact of Persistent Pulmonary Hypertension of the Newborn in Neonates with Dextro-transposition of the Great Arteries. J Cardiothorac Vasc Anesth. 2024;38(12):3109-3117.
   Abstract DOI PMID Cited by ~1
5. van Melzen R, Haveman ME, Schuurmann RCL, van Amsterdam K, Moumni ME, Tabak M, et al. Validity and Reliability of Wearable Sensors for Continuous Postoperative Vital Signs Monitoring in Patients Recovering from Trauma Surgery. Sensors (Basel). 2024;24(19).
   Abstract DOI PMID Cited by ~9
6. Kalmar AF, Teunkens A, Rex S, Vereecke H, Mulier H, Struys MMRF. System leaks and the loss of sevoflurane. Anaesthesia. 2024;79(9):1004-1005.
   DOI PMID Cited by ~2
7. Marges OM, Nieboer JP, de Keijzer IN, Rettab R, van Amsterdam K, Scheeren TWL, et al. Comparing the haemodynamic effects of high- and low-dose opioid anaesthesia: a secondary analysis of a randomised controlled trial. J Clin Monit Comput. 2024;38(6):1347-1355.
   Abstract DOI PMID
8. Vos IA, Lucassen FG, Bens BWJ, Dercksen B, Postma R, Jorna EMF, et al. Pre-hospital care after return of spontaneous circulation: Are we achieving our targets?. Resusc Plus. 2024;19:100691.
   Abstract DOI PMID Cited by ~3
9. Ramaswamy SM, Kuizenga MH, Weerink MAS, Vereecke HEM, Nagaraj SB, Struys MMRF. Do all sedatives promote biological sleep electroencephalogram patterns? A machine learning framework to identify biological sleep promoting sedatives using electroencephalogram. PLoS One. 2024;19(7):e0304413.
   Abstract DOI PMID Cited by ~1
10. Tasbihgou SR, Netkova M, Kalmar AF, Doorduin J, Struys MMRF, Schoemaker RG, et al. Correction: Brain changes due to hypoxia during light anaesthesia can be prevented by deepening anaesthesia; a study in rats. PLoS One. 2024;19(5):e0303455.
    Abstract DOI PMID
11. Mulier H, Struys MMRF, Vereecke H, Rex S, Teunkens A, Kalmar AF. Efficiency of CONTRAfluran™ in reducing sevoflurane pollution from maintenance anaesthesia in minimal flow end-tidal control mode for laparoscopic surgery: Efficiency of CONTRAfluran™. Anaesthesia. 2024;79(8):849-855.
    Abstract DOI PMID Cited by ~20
12. Steinkühler T, Yang S, Hu MA, Jainandunsing JS, Jager NM, Erasmus ME, et al. Ex Vivo Optimization of Donor Lungs with Inhaled Sevoflurane during Normothermic Ex Vivo Lung Perfusion (VITALISE): A Pilot and Feasibility Study in Sheep. Int J Mol Sci. 2024;25(4).
    Abstract DOI PMID Cited by ~1
13. Fechner J, El-Boghdadly K, Spahn DR, Motsch J, Struys MMRF, Duranteau O, et al. Anaesthetic efficacy and postinduction hypotension with remimazolam compared with propofol: a multicentre randomised controlled trial. Anaesthesia. 2024;79(4):410-422.
    Abstract DOI PMID Cited by ~58
14. Vellinga R, Introna M, van Amsterdam K, Zhou XYT, Smet TD, Jensen EW, et al. Implementation of a Bayesian based advisory tool for target-controlled infusion of propofol using qCON as control variable. J Clin Monit Comput. 2024;38(2):519-529.
    Abstract DOI PMID Cited by ~4
15. Vellinga R, Koomen JV, Eleveld DJ, Stöhr T, Pesic M, Struys MMRF, et al. Target-controlled Infusion of Remimazolam in Healthy Volunteers Shows Some Acute Tolerance. Anesthesiology. 2024;140(2):207-219.
    Abstract DOI PMID Cited by ~17

2023

Papers in international journals

1. Kroneisl M, Spraakman NA, Koomen JV, Hijazi Z, Hoogstra-Berends FH, Leuvenink HGD, et al. Peri-Operative Kinetics of Plasma Mitochondrial DNA Levels during Living Donor Kidney Transplantation. Int J Mol Sci. 2023;24(17).
   Abstract DOI PMID Cited by ~4
2. Vellinga R, Eleveld DJ, Struys MMRF, van den Berg JP. General purpose models for intravenous anesthetics, the next generation for target-controlled infusion and total intravenous anesthesia?. Curr Opin Anaesthesiol. 2023;36(5):602-607.
   Abstract DOI PMID Cited by ~8
3. van Melzen R, Haveman ME, Schuurmann RCL, Struys MMRF, de Vries JPM. Implementing Wearable Sensors for Clinical Application at a Surgical Ward: Points to Consider before Starting. Sensors (Basel). 2023;23(15).
   Abstract DOI PMID Cited by ~11
4. Carvalho H, Verdonck M, Eleveld DJ, Ramirez D, D'Haese J, Flamée P, et al. Neuromuscular end-point predictive capability of published rocuronium pharmacokinetic/pharmacodynamic models: An observational trial. J Clin Anesth. 2023;90:111225.
   Abstract DOI PMID Cited by ~1
5. Su H, Koomen JV, Eleveld DJ, Struys MMRF, Colin PJ. Pharmacodynamic mechanism-based interaction model for the haemodynamic effects of remifentanil and propofol in healthy volunteers. Br J Anaesth. 2023;131(2):222-233.
   Abstract DOI PMID Cited by ~12
6. Vos IA, Deuring E, Kwant M, Bens BWJ, Dercksen B, Postma R, et al. What is the potential benefit of pre-hospital extracorporeal cardiopulmonary resuscitation for patients with an out-of-hospital cardiac arrest? A predictive modelling study. Resuscitation. 2023;189:109825.
   Abstract DOI PMID Cited by ~13
7. Huisman GJJ, Spraakman NA, Koomen JV, Talsma AM, Pol RA, Berger SP, et al. Urinary Biomarkers in a Living Donor Kidney Transplantation Cohort-Predictive Value on Graft Function. Int J Mol Sci. 2023;24(6).
   Abstract DOI PMID Cited by ~2
8. Lambert DG, Struys MMRF, Howell S. British Journal of Anaesthesia: a leading publication and a registered charity. Br J Anaesth. 2023;130(1):7-8.
   Abstract DOI PMID Cited by ~2

2022

Papers in international journals

1. Vellinga R, Valk BI, Absalom AR, Struys MMRF, Barends CRM. What's New in Intravenous Anaesthesia? New Hypnotics, New Models and New Applications. J Clin Med. 2022;11(12).
   Abstract DOI PMID Cited by ~6
2. Vandemoortele O, Hannivoort LN, Vanhoorebeeck F, Struys MMRF, Vereecke HEM. General Purpose Pharmacokinetic-Pharmacodynamic Models for Target-Controlled Infusion of Anaesthetic Drugs: A Narrative Review. J Clin Med. 2022;11(9).
   Abstract DOI PMID Cited by ~31
3. Kuizenga MH, Vereecke HEM, Absalom AR, Bucher CH, Hannivoort LN, van den Berg JP, et al. Utility of the SmartPilot® View advisory screen to improve anaesthetic drug titration and postoperative outcomes in clinical practice: a two-centre prospective observational trial. Br J Anaesth. 2022;128(6):959-970.
   Abstract DOI PMID Cited by ~13
4. Su H, Eleveld DJ, Struys MMRF, Colin PJ. Mechanism-based pharmacodynamic model for propofol haemodynamic effects in healthy volunteers. Br J Anaesth. 2022;128(5):806-816.
   Abstract DOI PMID Cited by ~25
5. Bosch DJ, Nieuwenhuijs-Moeke GJ, van Meurs M, Abdulahad WH, Struys MMRF. Immune Modulatory Effects of Nonsteroidal Anti-inflammatory Drugs in the Perioperative Period and Their Consequence on Postoperative Outcome. Anesthesiology. 2022;136(5):843-860.
   Abstract DOI PMID Cited by ~42
6. Introna M, van den Berg JP, Eleveld DJ, Struys MMRF. Bayesian statistics in anesthesia practice: a tutorial for anesthesiologists. J Anesth. 2022;36(2):294-302.
   Abstract DOI PMID Cited by ~6
7. Eleveld DJ, Koomen JV, Absalom AR, Su H, Hannivoort LN, Struys MMRF. Allometric Scaling in Pharmacokinetic Studies in Anesthesiology. Anesthesiology. 2022;136(4):609-617.
   DOI PMID Cited by ~20
8. Alvarez-Jimenez R, Weerink MAS, Hannivoort LN, Su H, Struys MMRF, Loer SA, et al. Dexmedetomidine Clearance Decreases with Increasing Drug Exposure: Implications for Current Dosing Regimens and Target-controlled Infusion Models Assuming Linear Pharmacokinetics. Anesthesiology. 2022;136(2):279-292.
   Abstract DOI PMID Cited by ~10
9. Ramaswamy SM, Kuizenga MH, Weerink MAS, Vereecke HEM, Struys MMRF, Nagaraj SB. Frontal electroencephalogram based drug, sex, and age independent sedation level prediction using non-linear machine learning algorithms. J Clin Monit Comput. 2022;36(1):121-130.
   Abstract DOI PMID Cited by ~3

2021

Papers in international journals

1. Dercksen B, Struys MMRF, Cnossen F, Paans W. Qualitative development and content validation of the "SPART" model; a focused ethnography study of observable diagnostic and therapeutic activities in the emergency medical services care process. BMC Emerg Med. 2021;21(1):135.
   Abstract DOI PMID Cited by ~5
2. Struys MMRF, Eckelman MJ. Environmental Footprint of Anesthesia: More than Inhaled Anesthetics!. Anesthesiology. 2021;135(6):937-939.
   DOI PMID Cited by ~7
3. Eleveld DJ, Colin PJ, Hannivoort LN, Absalom AR, Struys MMRF. Comment on Morse et al. A Universal Pharmacokinetic Model for Dexmedetomidine in Children and Adults. J Clin Med. 2021;10(14).
   Abstract DOI PMID Cited by ~1
4. Stöhr T, Colin PJ, Ossig J, Pesic M, Borkett K, Winkle P, et al. Pharmacokinetic properties of remimazolam in subjects with hepatic or renal impairment. Br J Anaesth. 2021;127(3):415-423.
   Abstract DOI PMID Cited by ~156
5. Valk BI, Struys MMRF. Etomidate and its Analogs: A Review of Pharmacokinetics and Pharmacodynamics. Clin Pharmacokinet. 2021;60(10):1253-1269.
   Abstract DOI PMID Cited by ~107
6. Vellinga R, Hannivoort LN, Koomen JV, Colin P, Absalom AR, Struys MMRF, et al. Clinical validation of pharmacokinetic/pharmacodynamic models for propofol infusion. Response to Br J Anaesth 2021: 126: e172-4. Br J Anaesth. 2021;127(1):e3-e5.
   DOI PMID Cited by ~2
7. da Costa MG, Kalmar AF, Struys MMRF. Inhaled Anesthetics: Environmental Role, Occupational Risk, and Clinical Use. J Clin Med. 2021;10(6).
   Abstract DOI PMID Cited by ~66
8. Vellinga R, Hannivoort LN, Introna M, Touw DJ, Absalom AR, Eleveld DJ, et al. Prospective clinical validation of the Eleveld propofol pharmacokinetic-pharmacodynamic model in general anaesthesia. Br J Anaesth. 2021;126(2):386-394.
   Abstract DOI PMID Cited by ~70
9. Nieuwenhuijs-Moeke GJ, Nieuwenhuijs VB, Seelen MAJ, Berger SP, van den Heuvel MC, Burgerhof JGM, et al. Corrigendum to 'Propofol-based anaesthesia versus sevoflurane-based anaesthesia for living donor kidney transplantation: results of the VAPOR-1 randomized controlled trial' (Br J Anaesth 2017; 118: 720-32). Br J Anaesth. 2021;126(1):340-341.
   DOI PMID
10. Jonker PKC, van der Plas WY, Steinkamp PJ, Poelstra R, Emous M, van der Meij W, et al. Perioperative SARS-CoV-2 infections increase mortality, pulmonary complications, and thromboembolic events: A Dutch, multicenter, matched-cohort clinical study. Surgery. 2021;169(2):264-274.
    Abstract DOI PMID Cited by ~97
11. Eleveld DJ, Colin PJ, Absalom AR, Struys MMRF. Resisting neural inertia: an exercise in floccinaucinihilipilification?. Br J Anaesth. 2021;126(1):31-34.
    DOI PMID Cited by ~3
12. Valk BI, Eleveld DJ, Meyer P, Meier S, den Daas I, van Amsterdam K, et al. Modeling the Effect of Excitation on Depth of Anesthesia Monitoring in γ-Aminobutyric Acid Type A Receptor Agonist ABP-700. Anesthesiology. 2021;134(1):35-51.
    Abstract DOI PMID Cited by ~12
13. Ramaswamy SM, Weerink MAS, Struys MMRF, Nagaraj SB. Dexmedetomidine-induced deep sedation mimics non-rapid eye movement stage 3 sleep: large-scale validation using machine learning. Sleep. 2021;44(2).
    Abstract DOI PMID Cited by ~36
14. van den Berg JP, Absalom AR, Venema AM, Kalmar AF, Amsterdam KV, Hannivoort LN, et al. Comparison of haemodynamic- and electroencephalographic-monitored effects evoked by four combinations of effect-site concentrations of propofol and remifentanil, yielding a predicted tolerance to laryngoscopy of 90. J Clin Monit Comput. 2021;35(4):815-825.
    Abstract DOI PMID Cited by ~6

2020

Papers in international journals

1. Eleveld DJ, Struys MMRF. Meta-analysis of Ketamine Pharmacokinetics. Anesthesiology. 2020;133(6):1167-1169.
   DOI PMID Cited by ~3
2. Proost JH, Eleveld DJ, Struys MMRF. Population Pharmacodynamic Modeling Using the Sigmoid E. AAPS J. 2020;23(1):10.
   Abstract DOI PMID Cited by ~7
3. Poterman M, Kalmar AF, Buisman PL, Struys MMRF, Scheeren TWL. Improved haemodynamic stability and cerebral tissue oxygenation after induction of anaesthesia with sufentanil compared to remifentanil: a randomised controlled trial. BMC Anesthesiol. 2020;20(1):258.
   Abstract DOI PMID Cited by ~8
4. Sahinovic MM, van den Berg JP, Colin PJ, Gambus PL, Jensen EW, Agustí M, et al. Influence of an "Electroencephalogram-Based" Monitor Choice on the Delay Between the Predicted Propofol Effect-Site Concentration and the Measured Drug Effect. Anesth Analg. 2020;131(4):1184-1192.
   Abstract DOI PMID Cited by ~6
5. Barends CRM, Driesens MK, van Amsterdam K, Struys MMRF, Absalom AR. Moderate-to-Deep Sedation Using Target-Controlled Infusions of Propofol and Remifentanil: Adverse Events and Risk Factors: A Retrospective Cohort Study of 2937 Procedures. Anesth Analg. 2020;131(4):1173-1183.
   Abstract DOI PMID Cited by ~39
6. Bosch DJ, Meurs MV, Jongman RM, Heeringa P, Abdulahad WH, Struys MMRF. Effects of propofol and dexmedetomidine with and without remifentanil on serum cytokine concentrations in healthy volunteers: a post hoc analysis. Br J Anaesth. 2020;125(3):267-274.
   Abstract DOI PMID Cited by ~7
7. Eleveld DJ, Colin P, Absalom AR, Struys MMRF. Target-controlled-infusion models for remifentanil dosing consistent with approved recommendations. Br J Anaesth. 2020;125(4):483-491.
   Abstract DOI PMID Cited by ~45
8. Hannivoort LN, Absalom AR, Struys MMRF. The role of pharmacokinetics and pharmacodynamics in clinical anaesthesia practice. Curr Opin Anaesthesiol. 2020;33(4):483-489.
   Abstract DOI PMID Cited by ~12
9. Preckel B, Staender S, Arnal D, Brattebø G, Feldman JM, Ffrench-O'Carroll R, et al. Ten years of the Helsinki Declaration on patient safety in anaesthesiology: An expert opinion on peri-operative safety aspects. Eur J Anaesthesiol. 2020;37(7):521-610.
   Abstract DOI PMID Cited by ~62
10. Nieuwenhuijs-Moeke GJ, Jainandunsing JS, Struys MMRF. Sevoflurane, a sigh of relief in COVID-19?. Br J Anaesth. 2020;125(2):118-121.
    DOI PMID Cited by ~31
11. Nagaraj SB, Ramaswamy SM, Weerink MAS, Struys MMRF. Predicting Deep Hypnotic State From Sleep Brain Rhythms Using Deep Learning: A Data-Repurposing Approach. Anesth Analg. 2020;130(5):1211-1221.
    Abstract DOI PMID Cited by ~21
12. Zaouter C, Joosten A, Rinehart J, Struys MMRF, Hemmerling TM. Autonomous Systems in Anesthesia: Where Do We Stand in 2020? A Narrative Review. Anesth Analg. 2020;130(5):1120-1132.
    Abstract DOI PMID Cited by ~78
13. Barends CRM, Driesens MK, Struys MMRF, Visser A, Absalom AR. Intranasal dexmedetomidine in elderly subjects with or without beta blockade: a randomised double-blind single-ascending-dose cohort study. Br J Anaesth. 2020;124(4):411-419.
    Abstract DOI PMID Cited by ~16
14. Nieuwenhuijs-Moeke GJ, Pischke SE, Berger SP, Sanders JSF, Pol RA, Struys MMRF, et al. Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair. J Clin Med. 2020;9(1).
    Abstract DOI PMID Cited by ~240
15. Neckebroek M, Boldingh JHL, Smet TD, Struys MMRF. Influence of Remifentanil on the Control Performance of the Bispectral Index Controlled Bayesian-Based Closed-Loop System for Propofol Administration. Anesth Analg. 2020;130(6):1661-1669.
    Abstract DOI PMID Cited by ~17

2019

Papers in international journals

1. Jonckheere S, Neve ND, Verbeke J, Decker KD, Brandt I, Boel A, et al. Target-Controlled Infusion of Cefepime in Critically Ill Patients. Antimicrob Agents Chemother. 2019;64(1).
   Abstract DOI PMID Cited by ~11
2. Nieuwenhuijs-Moeke GJ, Huijink TM, Pol RA, Moumni ME, Burgerhof JG, Struys MM, et al. Intraoperative Fluid Restriction is Associated with Functional Delayed Graft Function in Living Donor Kidney Transplantation: A Retrospective Cohort Analysis. J Clin Med. 2019;8(10).
   Abstract DOI PMID Cited by ~11
3. Kuizenga MH, Colin PJ, Reyntjens KMEM, Touw DJ, Nalbat H, Knotnerus FH, et al. Population Pharmacodynamics of Propofol and Sevoflurane in Healthy Volunteers Using a Clinical Score and the Patient State Index: A Crossover Study. Anesthesiology. 2019;131(6):1223-1238.
   Abstract DOI PMID Cited by ~20
4. Weerink MAS, Barends CRM, Muskiet ERR, Reyntjens KMEM, Knotnerus FH, Oostra M, et al. Pharmacodynamic Interaction of Remifentanil and Dexmedetomidine on Depth of Sedation and Tolerance of Laryngoscopy. Anesthesiology. 2019;131(5):1004-1017.
   Abstract DOI PMID Cited by ~32
5. Welling JBA, Klooster K, Hartman JE, Kerstjens HAM, Franz I, Struys MMRF, et al. Collateral Ventilation Measurement Using Chartis: Procedural Sedation vs General Anesthesia. Chest. 2019;156(5):984-990.
   Abstract DOI PMID Cited by ~13
6. Ramaswamy SM, Kuizenga MH, Weerink MAS, Vereecke HEM, Struys MMRF, Nagaraj SB. Novel drug-independent sedation level estimation based on machine learning of quantitative frontal electroencephalogram features in healthy volunteers. Br J Anaesth. 2019;123(4):479-487.
   Abstract DOI PMID Cited by ~22
7. Hewson DW, Struys MMRF, Hardman JG. Opioids: refining the perioperative role of God's own medicine. Br J Anaesth. 2019;122(6):e93-e95.
   DOI PMID Cited by ~8
8. Coppens M, Limmen JGMV, Schnider T, Wyler B, Bonte S, Dewaele F, et al. Corrigendum to 'Study of the time course of the clinical effect of propofol compared with the time course of the predicted effect-site concentration: performance of three pharmacokinetic-dynamic models' [Br J Anaesth 2010; 104: 452-458]. Br J Anaesth. 2019;122(2):287.
   DOI PMID Cited by ~1
9. Coppens MJ, Versichelen LFM, Mortier EP, Struys MMRF. Corrigendum to 'Do we need inhaled anaesthetics to blunt arousal, haemodynamic responses to intubation after i.v. induction with propofol, remifentanil, rocuronium?' [Br J Anaesth 2006; 97: 835-841]. Br J Anaesth. 2019;122(2):286.
   DOI PMID Cited by ~1
10. Colin PJ, Allegaert K, Thomson AH, Touw DJ, Dolton M, de Hoog M, et al. Vancomycin Pharmacokinetics Throughout Life: Results from a Pooled Population Analysis and Evaluation of Current Dosing Recommendations. Clin Pharmacokinet. 2019;58(6):767-780.
    Abstract DOI PMID Cited by ~75
11. Neckebroek M, Ionescu CM, van Amsterdam K, Smet TD, Baets PD, Decruyenaere J, et al. A comparison of propofol-to-BIS post-operative intensive care sedation by means of target controlled infusion, Bayesian-based and predictive control methods: an observational, open-label pilot study. J Clin Monit Comput. 2019;33(4):675-686.
    Abstract DOI PMID Cited by ~58
12. Vos JJ, Willems CH, van Amsterdam K, van den Berg JP, Spanjersberg R, Struys MMRF, et al. Oxygen Reserve Index: Validation of a New Variable. Anesth Analg. 2019;129(2):409-415.
    Abstract DOI PMID Cited by ~56
13. Scheeren TWL, Kuizenga MH, Maurer H, Struys MMRF, Heringlake M. Electroencephalography and Brain Oxygenation Monitoring in the Perioperative Period. Anesth Analg. 2019;128(2):265-277.
    Abstract DOI PMID Cited by ~56

2018

Papers in international journals

1. Freeman L, Middeldorp J, van den Akker E, Oudijk M, Bax C, van Huizen M, et al. An economic analysis of patient controlled remifentanil and epidural analgesia as pain relief in labour (RAVEL trial); a randomised controlled trial. PLoS One. 2018;13(10):e0205220.
   Abstract DOI PMID Cited by ~8
2. Vogels MF, Struys MMRF, Scheeren TWL. The potential power and hidden hazards of Trial Sequential Analysis regarding viscoelastic blood tests in cardiac surgery. Comment on Br J Anaesth 2017; 118: 823-33. Br J Anaesth. 2018;121(4):977-978.
   DOI PMID
3. Barends CRM, Absalom AR, Struys MMRF. Drug selection for ambulatory procedural sedation. Curr Opin Anaesthesiol. 2018;31(6):673-678.
   Abstract DOI PMID Cited by ~44
4. Eleveld DJ, Colin P, Absalom AR, Struys MMRF. Corrigendum to "Pharmacokinetic-pharmacodynamic model for propofol for broad application in anaesthesia and sedation" [Br J Anaesth 2018; 120: 942-959]. Br J Anaesth. 2018;121(2):519.
   DOI PMID Cited by ~9
5. Colin PJ, Kuizenga MH, Vereecke HEM, Struys MMRF. Pharmacokinetic Pharmacodynamic Perspective on the Detection of Signs of Neural Inertia in Humans. Anesthesiology. 2018;129(2):373-375.
   DOI PMID Cited by ~5
6. Sahinovic MM, Struys MMRF, Absalom AR. Clinical Pharmacokinetics and Pharmacodynamics of Propofol. Clin Pharmacokinet. 2018;57(12):1539-1558.
   Abstract DOI PMID Cited by ~530
7. Nieuwenhuijs-Moeke GJ, van den Berg TAJ, Bakker SJL, van den Heuvel MC, Struys MMRF, Lisman T, et al. Preemptively and non-preemptively transplanted patients show a comparable hypercoagulable state prior to kidney transplantation compared to living kidney donors. PLoS One. 2018;13(7):e0200537.
   Abstract DOI PMID Cited by ~11
8. Valk BI, Absalom AR, Meyer P, Meier S, den Daas I, van Amsterdam K, et al. Safety and clinical effect of i.v. infusion of cyclopropyl-methoxycarbonyl etomidate (ABP-700), a soft analogue of etomidate, in healthy subjects. Br J Anaesth. 2018;120(6):1401-1411.
   Abstract DOI PMID Cited by ~35
9. Eleveld DJ, Colin P, Absalom AR, Struys MMRF. Pharmacokinetic-pharmacodynamic model for propofol for broad application in anaesthesia and sedation. Br J Anaesth. 2018;120(5):942-959.
   Abstract DOI PMID Cited by ~244
10. Kalmar AF, Allaert S, Pletinckx P, Maes J, Heerman J, Vos JJ, et al. Phenylephrine increases cardiac output by raising cardiac preload in patients with anesthesia induced hypotension. J Clin Monit Comput. 2018;32(6):969-976.
    Abstract DOI PMID Cited by ~58
11. Colin PJ, Jonckheere S, Struys MMRF. Target-Controlled Continuous Infusion for Antibiotic Dosing: Proof-of-Principle in an In-silico Vancomycin Trial in Intensive Care Unit Patients. Clin Pharmacokinet. 2018;57(11):1435-1447.
    Abstract DOI PMID Cited by ~22
12. Kuizenga MH, Colin PJ, Reyntjens KMEM, Touw DJ, Nalbat H, Knotnerus FH, et al. Test of neural inertia in humans during general anaesthesia. Br J Anaesth. 2018;120(3):525-536.
    Abstract DOI PMID Cited by ~43
13. Tasbihgou SR, Netkova M, Kalmar AF, Doorduin J, Struys MMRF, Schoemaker RG, et al. Brain changes due to hypoxia during light anaesthesia can be prevented by deepening anaesthesia; a study in rats. PLoS One. 2018;13(2):e0193062.
    Abstract DOI PMID Cited by ~9
14. Westerkamp AC, de Geus AF, Molenbuur B, Meyer P, Wietasch JKG, Struys MMRF, et al. Comparing peri-operative complications of paediatric and adult anaesthesia: A retrospective cohort study of 81 267 cases. Eur J Anaesthesiol. 2018;35(4):280-288.
    Abstract DOI PMID Cited by ~10
15. Hinkelbein J, Lamperti M, Akeson J, Santos J, Costa J, Robertis ED, et al. European Society of Anaesthesiology and European Board of Anaesthesiology guidelines for procedural sedation and analgesia in adults. Eur J Anaesthesiol. 2018;35(1):6-24.
    Abstract DOI PMID Cited by ~225

2017

Papers in international journals

1. van den Berg JP, Eleveld DJ, Smet TD, van den Heerik AVM, van Amsterdam K, Lichtenbelt BJ, et al. Influence of Bayesian optimization on the performance of propofol target-controlled infusion. Br J Anaesth. 2017;119(5):918-927.
   Abstract DOI PMID Cited by ~18
2. Saunders R, Struys MMRF, Pollock RF, Mestek M, Lightdale JR. Patient safety during procedural sedation using capnography monitoring: a systematic review and meta-analysis. BMJ Open. 2017;7(6):e013402.
   Abstract DOI PMID Cited by ~91
3. Nieuwenhuijs-Moeke GJ, Nieuwenhuijs VB, Seelen MAJ, Berger SP, van den Heuvel MC, Burgerhof JGM, et al. Propofol-based anaesthesia versus sevoflurane-based anaesthesia for living donor kidney transplantation: results of the VAPOR-1 randomized controlled trial. Br J Anaesth. 2017;118(5):720-732.
   Abstract DOI PMID Cited by ~49
4. Eleveld DJ, Proost JH, Vereecke H, Absalom AR, Olofsen E, Vuyk J, et al. An Allometric Model of Remifentanil Pharmacokinetics and Pharmacodynamics. Anesthesiology. 2017;126(6):1005-1018.
   Abstract DOI PMID Cited by ~114
5. Struys MMRF, Valk BI, Eleveld DJ, Absalom AR, Meyer P, Meier S, et al. A Phase 1, Single-center, Double-blind, Placebo-controlled Study in Healthy Subjects to Assess the Safety, Tolerability, Clinical Effects, and Pharmacokinetics-Pharmacodynamics of Intravenous Cyclopropyl-methoxycarbonylmetomidate (ABP-700) after a Single Ascending Bolus Dose. Anesthesiology. 2017;127(1):20-35.
   Abstract DOI PMID Cited by ~32
6. Poterman M, Scheeren TWL, van der Velde MI, Buisman PL, Allaert S, Struys MMRF, et al. Prophylactic atropine administration attenuates the negative haemodynamic effects of induction of anaesthesia with propofol and high-dose remifentanil: A randomised controlled trial. Eur J Anaesthesiol. 2017;34(10):695-701.
   Abstract DOI PMID Cited by ~20
7. Weerink MAS, Struys MMRF, Hannivoort LN, Barends CRM, Absalom AR, Colin P. Clinical Pharmacokinetics and Pharmacodynamics of Dexmedetomidine. Clin Pharmacokinet. 2017;56(8):893-913.
   Abstract DOI PMID Cited by ~860
8. Kuhlmann L, Manton JH, Heyse B, Vereecke HEM, Lipping T, Struys MMRF, et al. Tracking Electroencephalographic Changes Using Distributions of Linear Models: Application to Propofol-Based Depth of Anesthesia Monitoring. IEEE Trans Biomed Eng. 2017;64(4):870-881.
   Abstract DOI PMID Cited by ~7

2016

Papers in international journals

1. Carette R, Struys MMRF, Wolf AMD, Hendrickx JFA. Not Really Triple Low?. Anesthesiology. 2016;124(6):1410-1.
   DOI PMID
2. Kuizenga MH, Vereecke HEM, Struys MMRF. Model-based drug administration: current status of target-controlled infusion and closed-loop control. Curr Opin Anaesthesiol. 2016;29(4):475-81.
   Abstract DOI PMID Cited by ~22
3. Bosch DJ, Wang D, Nijsten MWN, Mul VEM, Hospers GAP, Burgerhof JGM, et al. Longitudinal analysis of cytokine expression during neoadjuvant chemoradiotherapy and subsequent surgery in esophageal cancer patients. Am J Surg. 2016;212(1):89-95.
   Abstract DOI PMID Cited by ~1
4. Kuhlmann L, Freestone DR, Manton JH, Heyse B, Vereecke HEM, Lipping T, et al. Neural mass model-based tracking of anesthetic brain states. Neuroimage. 2016;133:438-456.
   Abstract DOI PMID Cited by ~48
5. Hoekstra M, Hessels L, Rienstra M, Yeh L, Lansink AO, Vogelzang M, et al. Computer-guided normal-low versus normal-high potassium control after cardiac surgery: No impact on atrial fibrillation or atrial flutter. Am Heart J. 2016;172:45-52.
   Abstract DOI PMID Cited by ~9
6. Colin P, Eleveld DJ, van den Berg JP, Vereecke HEM, Struys MMRF, Schelling G, et al. Propofol Breath Monitoring as a Potential Tool to Improve the Prediction of Intraoperative Plasma Concentrations. Clin Pharmacokinet. 2016;55(7):849-859.
   Abstract DOI PMID Cited by ~35
7. Struys MMRF, Smet TD, Glen JIB, Vereecke HEM, Absalom AR, Schnider TW. The History of Target-Controlled Infusion. Anesth Analg. 2016;122(1):56-69.
   Abstract DOI PMID Cited by ~127
8. Schnider TW, Minto CF, Struys MMRF, Absalom AR. The Safety of Target-Controlled Infusions. Anesth Analg. 2016;122(1):79-85.
   Abstract DOI PMID Cited by ~77
9. Absalom AR, Glen JIB, Zwart GJC, Schnider TW, Struys MMRF. Target-Controlled Infusion: A Mature Technology. Anesth Analg. 2016;122(1):70-8.
   Abstract DOI PMID Cited by ~158

2015

Papers in international journals

1. Vos JJ, Poterman M, Salm PP, Amsterdam KV, Struys MMRF, Scheeren TWL, et al. Noninvasive pulse pressure variation and stroke volume variation to predict fluid responsiveness at multiple thresholds: a prospective observational study. Can J Anaesth. 2015;62(11):1153-60.
   Abstract DOI PMID Cited by ~33
2. Poterman M, Vos JJ, Vereecke HEM, Struys MMRF, Vanoverschelde H, Scheeren TWL, et al. Differential effects of phenylephrine and norepinephrine on peripheral tissue oxygenation during general anaesthesia: A randomised controlled trial. Eur J Anaesthesiol. 2015;32(8):571-80.
   Abstract DOI PMID Cited by ~46

2014

Papers in international journals

1. Vos JJ, Poterman M, Hannivoort LN, Lavalette VWRD, Struys MM, Scheeren TW, et al. Hemodynamics and tissue oxygenation during balanced anesthesia with a high antinociceptive contribution: an observational study. Perioper Med (Lond). 2014;3:9.
   Abstract DOI PMID Cited by ~8
2. Vos JJ, Poterman M, Mooyaart EAQ, Weening M, Struys MMRF, Scheeren TWL, et al. Comparison of continuous non-invasive finger arterial pressure monitoring with conventional intermittent automated arm arterial pressure measurement in patients under general anaesthesia. Br J Anaesth. 2014;113(1):67-74.
   Abstract DOI PMID Cited by ~68

2013

Papers in international journals

1. Vos JJ, Kalmar AF, Struys MMRF, Wietasch JKG, Hendriks HGD, Scheeren TWL. Comparison of arterial pressure and plethysmographic waveform-based dynamic preload variables in assessing fluid responsiveness and dynamic arterial tone in patients undergoing major hepatic resection. Br J Anaesth. 2013;110(6):940-6.
   Abstract DOI PMID Cited by ~51

Book chapters

1. Struys MMRF, Smet TD. Target-controlled infusions and closed-loop administration. In: Anesthetic Pharmacology. Cambridge University Press; 2013. p. 103-122.
   DOI Cited by ~2

2012

Papers in international journals

1. Vos JJ, Kalmar AF, Struys MMRF, Porte RJ, Wietasch JKG, Scheeren TWL, et al. Accuracy of non-invasive measurement of haemoglobin concentration by pulse co-oximetry during steady-state and dynamic conditions in liver surgery. Br J Anaesth. 2012;109(4):522-8.
   Abstract DOI PMID Cited by ~55

2011

Papers in international journals

1. Struys MMRF, Sahinovic M, Lichtenbelt BJ, Vereecke HEM, Absalom AR. Optimizing intravenous drug administration by applying pharmacokinetic/pharmacodynamic concepts. Br J Anaesth. 2011;107(1):38-47.
   Abstract DOI PMID Cited by ~58

2010

Papers in international journals

1. Lichtenbelt BJ, Olofsen E, Dahan A, van Kleef JW, Struys MMRF, Vuyk J. Propofol reduces the distribution and clearance of midazolam. Anesth Analg. 2010;110(6):1597-606.
   Abstract DOI PMID Cited by ~36

2007

Books

1. Bellamy M, Bellamy M, Struys M, Struys M. Anaesthesia for the Overweight and Obese PatientAnaesthesia for the Overweight and Obese Patient. Oxford University Press; 2007.
   DOI Cited by ~3

Book chapters

1. Bellamy M, Struys M. Chapter 7 Pre-operative assessment and preparation. In: Bellamy M, Struys M, editors. Anaesthesia for the Overweight and Obese PatientAnaesthesia for the Overweight and Obese Patient. Oxford University Press; 2007.
   DOI
2. Bellamy M, Struys M. Chapter 1 Definitions, social trends, and epidemiology. In: Bellamy M, Struys M, editors. Anaesthesia for the Overweight and Obese PatientAnaesthesia for the Overweight and Obese Patient. Oxford University Press; 2007.
   DOI
3. Bellamy M, Struys M. Chapter 9 Obesity and the airway. In: Bellamy M, Struys M, editors. Anaesthesia for the Overweight and Obese PatientAnaesthesia for the Overweight and Obese Patient. Oxford University Press; 2007.
   DOI
4. Bellamy M, Struys M. Chapter 4 Obesity co-morbidities. In: Bellamy M, Struys M, editors. Anaesthesia for the Overweight and Obese PatientAnaesthesia for the Overweight and Obese Patient. Oxford University Press; 2007.
   DOI
5. Bellamy M, Struys M. Chapter 8 Practical conduct of anaesthesia and the anaesthetic environment. In: Bellamy M, Struys M, editors. Anaesthesia for the Overweight and Obese PatientAnaesthesia for the Overweight and Obese Patient. Oxford University Press; 2007.
   DOI
6. Bellamy M, Struys M. Chapter 10 Recovery and post-operative care. In: Bellamy M, Struys M, editors. Anaesthesia for the Overweight and Obese PatientAnaesthesia for the Overweight and Obese Patient. Oxford University Press; 2007.
   DOI
7. Bellamy M, Struys M. Chapter 6 Anaesthetic pharmacology and obesity. In: Bellamy M, Struys M, editors. Anaesthesia for the Overweight and Obese PatientAnaesthesia for the Overweight and Obese Patient. Oxford University Press; 2007.
   DOI
8. Bellamy M, Struys M. Chapter 3 Obesity and systemic physiology. In: Bellamy M, Struys M, editors. Anaesthesia for the Overweight and Obese PatientAnaesthesia for the Overweight and Obese Patient. Oxford University Press; 2007.
   DOI
9. Bellamy M, Struys M. Chapter 11 Bariatric surgery and post-operative outcome. In: Bellamy M, Struys M, editors. Anaesthesia for the Overweight and Obese PatientAnaesthesia for the Overweight and Obese Patient. Oxford University Press; 2007.
   DOI
10. Bellamy M, Struys M. Chapter 5 Disorders of sleep and respiratory control in obesity: perioperative assessment and management. In: Bellamy M, Struys M, editors. Anaesthesia for the Overweight and Obese PatientAnaesthesia for the Overweight and Obese Patient. Oxford University Press; 2007.
    DOI
11. Bellamy M, Struys M. Chapter 2 Physiology of obesity, molecular, and medical approaches. In: Bellamy M, Struys M, editors. Anaesthesia for the Overweight and Obese PatientAnaesthesia for the Overweight and Obese Patient. Oxford University Press; 2007.
    DOI

2003

Papers in international journals

1. Mortier E, Struys M. Effect site modelling and its application in TCI. Adv Exp Med Biol. 2003;523:239-44.
   DOI PMID Cited by ~1

Book chapters

1. Mortier EP, Struys MMRF. Effect Site Modelling and Its Application in TCI. In: Vuyk J, Schraag S, editors. Advances in Experimental Medicine and Biology. Boston, MA: Springer US; 2003. p. 239-244.
   DOI Cited by ~1

2002

Papers in international journals

1. Cammu G, Bossuyt G, Baerdemaeker LD, Blauwen ND, Struys M, Mortier E. Dose requirements and recovery profile of an infusion of cisatracurium during liver transplantation. J Clin Anesth. 2002;14(2):135-9.
   Abstract DOI PMID Cited by ~10

2000

Book chapters

1. Struys M, Mortier E, Versichelen L. Strategies to Prevent Awareness. In: Vuyk J, Engbers F, Groen-Mulder S, editors. On the Study and Practice of Intravenous Anaesthesia. Dordrecht: Springer Netherlands; 2000. p. 113-127.
   DOI